Charles Winter, formerly with Denali Therapeutics joins Synthorx, Inc. La Jolla, CA as Vice President, CMC.

Synthorx Expands Leadership Team:

SAN DIEGO, July 12, 2018 – Synthorx, Inc., a biotechnology company using synthetic biology to discover and develop novel protein therapeutics, announced today the appointment Charles M. Winter, Vice President, Chemistry, Manufacturing, and Controls (CMC).

“We are pleased to add these talented individuals – each with an impressive track record of leadership and significant accomplishments and experience – to our team,” said Laura Shawver, Ph.D., President, CEO, and Director of Synthorx. “We believe each of them will be important to Synthorx as we advance our pipeline of Synthorin™ cytokines, including Synthorin IL-2, and pursue our goal of demonstrating that our technology can create tailored medicines that offer improvements over current treatments with the ability to help people with serious diseases.”

Mr. Charles M. Winter has deep experience in advancing biologic manufacturing in all phases of the drug development pipeline, as well as important expertise in managing U.S. and ex-U.S. regulatory interactions. Prior to Synthorx, he was Head of Biologics CMC for the Denali Therapeutics pipeline. Before joining Denali, Mr. Winter was Vice President, Manufacturing and Technology at JHL Biotech, where he executed strategic deals for developing and manufacturing biologics in Taiwan and China. Previously at Gilead and at Genentech, Mr. Winter was a core member of a start-up team for a new GMP facility and developed processes for multiple investigational new drug applications. Mr. Winter received a B.S. in chemical engineering from University of Wisconsin-Madison.

About Synthorx

Synthorx, Inc. is a biotechnology company using synthetic biology to discover and develop novel protein therapeutics. Synthorx’s expanded genetic alphabet platform has the ability to drive the site-specific incorporation of multiple synthetic amino acids into proteins, thereby tuning receptor specificity important for improving efficacy and safety. In addition, the company’s engineered organisms provide the ability to manufacture these improved proteins, called Synthorins, with the required fidelity and yield. The Synthorx platform expands the chemical and structural repertoire of protein therapeutics and uncovers new ways to modulate pharmacological properties of biologics. The company was founded based on important discoveries in Dr. Floyd Romesberg’s lab at The Scripps Research Institute in conjunction with Avalon Ventures. The company is headquartered in La Jolla, Calif.